11/30/2022 8:56:54 AM 6041 Hainaut

(Senior) Scientist Protein Engineering


  • NeuVasQ Biotechnologies
  • 6041 Hainaut
  • Pharmaceutical and Healthcare
  • Indefinite period
  • Permanent contract
  • Fulltime
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NeuVasQ Biotechnologies, a spin-off from the Université Libre de Bruxelles (ULB), is developing pharmaceuticals to sustain or restore neurovascular function, a novel mechanism to interfere with disease progression for the benefit of millions of patients affected by neurological disorders.

More information

Position

To help drive the discovery and optimization of the neurovascular/BBB-focused pharmaceuticals, NeuVasQ is looking for a (Senior) Scientist in Protein Engineering. The person in this role will join the Discovery team.

The position is based in the Brussels South Charleroi Biopark, Belgium.  

  • Drive the discovery, optimization and early development of newly engineered proteins and antibodies that activate specific pathways associated with the function of the BBB
  • Leverage structural biology insights as well as known protein interactions to propose novel protein and antibody designs
  • Work with other scientists in the Discovery team to develop in vitro and cell-based assays to allow primary and secondary screens of protein and antibody libraries at high-throughput
  • Design, synthesize, and screen/evaluate protein and antibody libraries to identify and select the most promising constructs
  • Conduct comprehensive physico-chemical and functional characterizations of selected proteins and antibodies and implement sequence optimization strategies to improve performance against target profiles and criteria
  • Collaborate with other scientists for the in vivo evaluation of selected proteins and antibodies in relevant disease models
  • Establish and oversee collaborations with CROs where relevant, e.g. to increase scale and/or throughput

Profile

  • Solid expertise in structural biology and protein chemistry, with a proven track record of protein and antibody engineering to generate novel therapeutics
  • Experience developing protein and antibody agonists that target membrane proteins and signalling pathways
  • Deep knowledge and experience with a range of protein engineering approaches, including rational design, screening and selection methods
  • Deep knowledge and experience with distinct antibody formats, including nanobodies
  • Knowledge of critical issues in drug discovery
  • Strong sense of practical execution, with focus on achieving company milestonesTeamwork experience, preferably in a biotech start-up environment 

Minimum qualifications

  • At least 5 years of proven industry experience in the discovery and engineering of both novel therapeutic protein and antibodies
  • A Ph.D. degree, plus post-doctoral or similar experience, in biochemistry, structural biology, chemical engineering, molecular biology, chemistry, or similar fields.

Offer

  • The challenge and excitement of an expanding start-up
  • Close collaboration with the founders and a great international team of experts in science
  • The possibility to boost your experience and career
  • You will join a highly motivated, international and dynamic team

Interested?

Contact your consultant

Lorane Molineaux

+32 478 50 77 03

Apply online

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