30-11-22 08:56:54 6041 Hainaut

(Senior) Scientist Protein Engineering


  • NeuVasQ Biotechnologies
  • 6041 Hainaut
  • Pharma & Soins de santé
  • Durée indéterminée
  • Contrat permanent
  • A plein temps
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NeuVasQ Biotechnologies, a spin-off from the Université Libre de Bruxelles (ULB), is developing pharmaceuticals to sustain or restore neurovascular function, a novel mechanism to interfere with disease progression for the benefit of millions of patients affected by neurological disorders.

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Position

To help drive the discovery and optimization of the neurovascular/BBB-focused pharmaceuticals, NeuVasQ is looking for a (Senior) Scientist in Protein Engineering. The person in this role will join the Discovery team.

The position is based in the Brussels South Charleroi Biopark, Belgium.  

  • Drive the discovery, optimization and early development of newly engineered proteins and antibodies that activate specific pathways associated with the function of the BBB
  • Leverage structural biology insights as well as known protein interactions to propose novel protein and antibody designs
  • Work with other scientists in the Discovery team to develop in vitro and cell-based assays to allow primary and secondary screens of protein and antibody libraries at high-throughput
  • Design, synthesize, and screen/evaluate protein and antibody libraries to identify and select the most promising constructs
  • Conduct comprehensive physico-chemical and functional characterizations of selected proteins and antibodies and implement sequence optimization strategies to improve performance against target profiles and criteria
  • Collaborate with other scientists for the in vivo evaluation of selected proteins and antibodies in relevant disease models
  • Establish and oversee collaborations with CROs where relevant, e.g. to increase scale and/or throughput

Profile

  • Solid expertise in structural biology and protein chemistry, with a proven track record of protein and antibody engineering to generate novel therapeutics
  • Experience developing protein and antibody agonists that target membrane proteins and signalling pathways
  • Deep knowledge and experience with a range of protein engineering approaches, including rational design, screening and selection methods
  • Deep knowledge and experience with distinct antibody formats, including nanobodies
  • Knowledge of critical issues in drug discovery
  • Strong sense of practical execution, with focus on achieving company milestonesTeamwork experience, preferably in a biotech start-up environment 

Minimum qualifications

  • At least 5 years of proven industry experience in the discovery and engineering of both novel therapeutic protein and antibodies
  • A Ph.D. degree, plus post-doctoral or similar experience, in biochemistry, structural biology, chemical engineering, molecular biology, chemistry, or similar fields.

Offer

  • The challenge and excitement of an expanding start-up
  • Close collaboration with the founders and a great international team of experts in science
  • The possibility to boost your experience and career
  • You will join a highly motivated, international and dynamic team

Intéressé(e)?

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Lorane Molineaux

+32 478 50 77 03

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